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These are very superficial injections using Dextrose in a dilute solution (5%). We inject around skin nerves and this results in almost immediate pain relief. Perineuronal injections are injected around the peripheral nerve pathways in order to target the pain fibers (c-fibers) of the pathway to reduce and eliminate pain from the nerve.
The painful nerves under the skin are injected with the dilute dextrose solution, which will almost immediately shut off production of the painful stimulus and substances around the inflamed nerve ending. It has been postulated that dextrose solution works at the cellular level on the TRVP1 receptors to decrease substance P and other neurochemicals that produce pain and inflame the nerve fiber. Dextrose solution also affects the ion channels of the nerve to aid in healing the nerve fiber at a cellular level.
You can expect perineural therapy to be extremely tolerable. Though you may experience some minor discomfort during the actual injections, the procedure is usually very well tolerated and patients do not typically experience any substantial pain. The injections are done with a very small needle (insulin needle size) and are injected superficially, right beneath the subcutaneous tissue layer. You will be seated or lying comfortably during the injections, and the number of total injections depends on how many peripheral nerve pathways are being treated during the procedure.
Once your injections are complete, you may experience immediate decreased pain sensation to palpation. The doctor will “test” the pain by trying to reproduce the discomfort with pressing over previously painful inflamed nerves beneath the skin surface. If the therapy was successful, you may experience some temporary early relief or a numbing like effect immediately post procedure. This positive diagnostic feedback. Post injection you’ll be free to resume your normal daily routine right away, without any restrictions on your activity. In terms of side effects, you may experience some minor tenderness and bruising at the injection site, but it should be mild and will resolve fairly quickly.
Depending on the severity and chronicity of injury, you may require multiple injections. Most of our patients return to the office for an additional two to six weekly sessions.
Because perineuronal injections are an all-natural, minimally-invasive way to treat chronic pain and inflammation, it’s typically a safe approach for most of our patients–especially those who would prefer to avoid traditional pharmaceutical pain relief options.
As long as you’re suffering from a condition that the treatment can successfully address, such as tendinitis or arthritis, there’s a very strong chance that you can benefit from perineural therapy. To be sure, we invite you to schedule an initial consultation today, so we can review your condition and medical history and help you determine if this treatment approach is in your best interest.